Discrimination is implicated in poor mental and physical health across racially minoritized groups. However, for whom, how, and in which contexts do the effects of discrimination impart its effects on the health of these diverse groups remains ripe for scientific inquiry. Intersectionality perspectives (Crenshaw, 1990; Cole, 2009) suggest that social positionalities can shape exposure to discriminatory experiences, processes, and outcomes resulting from discrimination in distinct and similar ways depending on the meaning interlocking structural identities take in specific contexts. In this symposium, we present findings from three studies based on population-based samples of racially minoritized groups (e.g., Black, Latinx, Asians) that examine factors--at multiple levels--that shape exposure to discrimination across different contexts (low vs. high-status occupations; geographic and cultural contexts), mediating mechanisms (i.e., sense of belonging), and the moderating effects of culturally-relevant individual difference factors (i.e., ethnic identity centrality) on associations between discrimination and indicators of health (i.e., mental health symptoms, health-related quality of life). Overall, findings from the three papers have implications for targeted and context-specific, multi-level preventative programs and interventions that address the social patterning of discrimination and the similar and unique effects of discrimination on racially minoritized groups.